光学频分复用：生物医学成像的新前沿

菅野寛志; 周雨奇; 合田圭介

doi:10.13756/j.gtxyj.2025.250117

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光学频分复用：生物医学成像的新前沿

专题：纪念创刊50周年 | 更新时间：2025-12-25

- 光学频分复用：生物医学成像的新前沿
- Frequency-Division Multiplexing: A New Frontier in Biomedical Imaging
- 光通信研究 2025年第6期
- 作者机构：
  
  1.东京大学　化学系，日本　东京　113-0033
  2.东北大学　神经外科工程与转化神经科学系，日本　宫城　980-8575
  3.武汉大学　科技研究院，武汉　430072
  4.加州大学洛杉矶分校　生物工程系，美国　加利福尼亚州　90095
  5.东北大学　国际同步辐射创新中心，日本　宫城　980-8577
- 作者简介：
  
  菅野寛志（1992-），男，日本大阪人。助理教授，博士，主要研究方向为生物光子学。
  合田圭介，教授。E-mail：keisukegoda@g.ecc.u-tokyo.ac.jp
- 基金信息：
  
  日本学术振兴会科研费资助项目(JSPS KAKENHI;24K18149);武田科学振兴财团、中谷医疗科学振兴财团、柯尼卡美能达“光之未来激励奖”以及“柯尼卡美能达影像科学杰出鼓励奖”资助项目
- DOI：10.13756/j.gtxyj.2025.250117
  中图分类号： Q334
- 收稿：2025-03-26，
  
  修回：2025-05-22，
  
  纸质出版：2025-12-10
- 稿件说明：
移动端阅览
菅野寛志，周雨奇，合田圭介. 光学频分复用：生物医学成像的新前沿[J]. 光通信研究，2025(6): 250117.

Kanno H, Zhou Y Q, Goda K. Frequency-Division Multiplexing: A New Frontier in Biomedical Imaging[J]. Study on Optical Communications, 2025(6): 250117.
菅野寛志，周雨奇，合田圭介. 光学频分复用：生物医学成像的新前沿[J]. 光通信研究，2025(6): 250117. DOI： 10.13756/j.gtxyj.2025.250117.

Kanno H, Zhou Y Q, Goda K. Frequency-Division Multiplexing: A New Frontier in Biomedical Imaging[J]. Study on Optical Communications, 2025(6): 250117. DOI： 10.13756/j.gtxyj.2025.250117.

摘要

文章介绍了光学频分复用（FDM）成像的原理及其在生物医学中的应用。此外，文章还探讨了该技术面临的挑战及其应对策略。FDM成像利用声光偏转器生成强度调制的光束阵列，用于样品照明与激发，同时通过单像素光电探测器进行光信号检测。该技术能够实现高速体积成像和高通量成像流式细胞术。凭借其独特的能力，FDM成像在神经科学、血液学和细胞生物学等领域展现出了广阔的应用前景。

Abstract

This review introduces the principles of optical Frequency Division Multiplexed (FDM) imaging and its biomedical applications. Additionally

the article explores the challenges faced by this technology and the corresponding approaches to address them. FDM imaging utilizes acousto-optic deflectors to generate an intensity-modulated beam array for sample illumination and excitation

while detecting light signals with a single-pixel photodetector. This technique enables high-speed volumetric imaging and high-throughput imaging flow cytometry. With its unique capabilities

FDM imaging holds great potential for broader applications in fields

such as neurology

hematology

and cell biology.

关键词

Keywords

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